A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.
Identifieur interne : 000227 ( Main/Exploration ); précédent : 000226; suivant : 000228A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.
Auteurs : Mengnan Zeng [République populaire de Chine] ; Meng Li [République populaire de Chine] ; Yingjie Chen [Hong Kong] ; Jingke Zhang [République populaire de Chine] ; Yangang Cao [République populaire de Chine] ; Beibei Zhang [République populaire de Chine] ; Weisheng Feng [République populaire de Chine] ; Xiaoke Zheng [République populaire de Chine] ; Zhiling Yu [Hong Kong]Source :
- Archives of biochemistry and biophysics [ 1096-0384 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Chrysanthemum (composition chimique), Cytokines (composition chimique), Découverte de médicament (MeSH), Extraits de plantes (composition chimique), Fleurs (composition chimique), Humains (MeSH), Inflammation (métabolisme), Lipopolysaccharides (composition chimique), Myocytes cardiaques (métabolisme), Médiateurs de l'inflammation (métabolisme), Polyynes (composition chimique), Polyynes (pharmacologie), Relation structure-activité (MeSH), Récepteur de type Toll-4 (métabolisme), Simulation de docking moléculaire (MeSH), Structure moléculaire (MeSH), Transduction du signal (MeSH).
- MESH :
- composition chimique : Chrysanthemum, Cytokines, Extraits de plantes, Fleurs, Lipopolysaccharides, Polyynes.
- métabolisme : Inflammation, Myocytes cardiaques, Médiateurs de l'inflammation, Récepteur de type Toll-4.
- pharmacologie : Polyynes.
- Animaux, Découverte de médicament, Humains, Relation structure-activité, Simulation de docking moléculaire, Structure moléculaire, Transduction du signal.
English descriptors
- KwdEn :
- Animals (MeSH), Chrysanthemum (chemistry), Cytokines (chemistry), Drug Discovery (MeSH), Flowers (chemistry), Humans (MeSH), Inflammation (metabolism), Inflammation Mediators (metabolism), Lipopolysaccharides (chemistry), Molecular Docking Simulation (MeSH), Molecular Structure (MeSH), Myocytes, Cardiac (metabolism), Plant Extracts (chemistry), Polyynes (chemistry), Polyynes (pharmacology), Signal Transduction (MeSH), Structure-Activity Relationship (MeSH), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , chemistry : Cytokines, Lipopolysaccharides, Plant Extracts, Polyynes.
- chemistry : Chrysanthemum, Flowers.
- metabolism : Inflammation, Inflammation Mediators, Myocytes, Cardiac, Toll-Like Receptor 4.
- chemical , pharmacology : Polyynes.
- Animals, Drug Discovery, Humans, Molecular Docking Simulation, Molecular Structure, Signal Transduction, Structure-Activity Relationship.
Abstract
A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.
DOI: 10.1016/j.abb.2020.108506
PubMed: 32679197
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Weisheng" sort="Feng, Weisheng" uniqKey="Feng W" first="Weisheng" last="Feng">Weisheng Feng</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Xiaoke" sort="Zheng, Xiaoke" uniqKey="Zheng X" first="Xiaoke" last="Zheng">Xiaoke Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. 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The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yingjie" sort="Chen, Yingjie" uniqKey="Chen Y" first="Yingjie" last="Chen">Yingjie Chen</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong</wicri:regionArea><wicri:noRegion>Kowloon Tong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jingke" sort="Zhang, Jingke" uniqKey="Zhang J" first="Jingke" last="Zhang">Jingke Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Yangang" sort="Cao, Yangang" uniqKey="Cao Y" first="Yangang" last="Cao">Yangang Cao</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Beibei" sort="Zhang, Beibei" uniqKey="Zhang B" first="Beibei" last="Zhang">Beibei Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Weisheng" sort="Feng, Weisheng" uniqKey="Feng W" first="Weisheng" last="Feng">Weisheng Feng</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Xiaoke" sort="Zheng, Xiaoke" uniqKey="Zheng X" first="Xiaoke" last="Zheng">Xiaoke Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046</wicri:regionArea><wicri:noRegion>450046</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Zhiling" sort="Yu, Zhiling" uniqKey="Yu Z" first="Zhiling" last="Yu">Zhiling Yu</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong</wicri:regionArea><wicri:noRegion>Kowloon Tong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archives of biochemistry and biophysics</title><idno type="eISSN">1096-0384</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Chrysanthemum (chemistry)</term><term>Cytokines (chemistry)</term><term>Drug Discovery (MeSH)</term><term>Flowers (chemistry)</term><term>Humans (MeSH)</term><term>Inflammation (metabolism)</term><term>Inflammation Mediators (metabolism)</term><term>Lipopolysaccharides (chemistry)</term><term>Molecular Docking Simulation (MeSH)</term><term>Molecular Structure (MeSH)</term><term>Myocytes, Cardiac (metabolism)</term><term>Plant Extracts (chemistry)</term><term>Polyynes (chemistry)</term><term>Polyynes (pharmacology)</term><term>Signal Transduction (MeSH)</term><term>Structure-Activity Relationship (MeSH)</term><term>Toll-Like Receptor 4 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Chrysanthemum (composition chimique)</term><term>Cytokines (composition chimique)</term><term>Découverte de médicament (MeSH)</term><term>Extraits de plantes (composition chimique)</term><term>Fleurs (composition chimique)</term><term>Humains (MeSH)</term><term>Inflammation (métabolisme)</term><term>Lipopolysaccharides (composition chimique)</term><term>Myocytes cardiaques (métabolisme)</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Polyynes (composition chimique)</term><term>Polyynes (pharmacologie)</term><term>Relation structure-activité (MeSH)</term><term>Récepteur de type Toll-4 (métabolisme)</term><term>Simulation de docking moléculaire (MeSH)</term><term>Structure moléculaire (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cytokines</term><term>Lipopolysaccharides</term><term>Plant Extracts</term><term>Polyynes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Chrysanthemum</term><term>Flowers</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Chrysanthemum</term><term>Cytokines</term><term>Extraits de plantes</term><term>Fleurs</term><term>Lipopolysaccharides</term><term>Polyynes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Inflammation Mediators</term><term>Myocytes, Cardiac</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Inflammation</term><term>Myocytes cardiaques</term><term>Médiateurs de l'inflammation</term><term>Récepteur de type Toll-4</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Polyynes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Polyynes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Discovery</term><term>Humans</term><term>Molecular Docking Simulation</term><term>Molecular Structure</term><term>Signal Transduction</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Découverte de médicament</term><term>Humains</term><term>Relation structure-activité</term><term>Simulation de docking moléculaire</term><term>Structure moléculaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32679197</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0384</ISSN><JournalIssue CitedMedium="Internet"><Volume>690</Volume><PubDate><Year>2020</Year><Month>09</Month><Day>15</Day></PubDate></JournalIssue><Title>Archives of biochemistry and biophysics</Title><ISOAbbreviation>Arch Biochem Biophys</ISOAbbreviation></Journal><ArticleTitle>A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.</ArticleTitle><Pagination><MedlinePgn>108506</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0003-9861(20)30515-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.abb.2020.108506</ELocationID><Abstract><AbstractText>A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Mengnan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yingjie</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jingke</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Yangang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Beibei</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Weisheng</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Xiaoke</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Zhiling</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Biochem Biophys</MedlineTA><NlmUniqueID>0372430</NlmUniqueID><ISSNLinking>0003-9861</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C524031">dendrazawayne A</NameOfSubstance></Chemical><Chemical><RegistryNumber>25067-58-7</RegistryNumber><NameOfSubstance UI="D053279">Polyynes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031202" MajorTopicYN="N">Chrysanthemum</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035264" MajorTopicYN="N">Flowers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032383" MajorTopicYN="N">Myocytes, Cardiac</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053279" MajorTopicYN="N">Polyynes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Bisepoxylignan</Keyword><Keyword MajorTopicYN="Y">Cardiomyocyte</Keyword><Keyword MajorTopicYN="Y">Dendranlignan A</Keyword><Keyword MajorTopicYN="Y">Structural elucidation</Keyword><Keyword MajorTopicYN="Y">TLR4</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32679197</ArticleId><ArticleId IdType="pii">S0003-9861(20)30515-4</ArticleId><ArticleId IdType="doi">10.1016/j.abb.2020.108506</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Mengnan" sort="Zeng, Mengnan" uniqKey="Zeng M" first="Mengnan" last="Zeng">Mengnan Zeng</name></noRegion><name sortKey="Cao, Yangang" sort="Cao, Yangang" uniqKey="Cao Y" first="Yangang" last="Cao">Yangang Cao</name><name sortKey="Feng, Weisheng" sort="Feng, Weisheng" uniqKey="Feng W" first="Weisheng" last="Feng">Weisheng Feng</name><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><name sortKey="Zhang, Beibei" sort="Zhang, Beibei" uniqKey="Zhang B" first="Beibei" last="Zhang">Beibei Zhang</name><name sortKey="Zhang, Jingke" sort="Zhang, Jingke" uniqKey="Zhang J" first="Jingke" last="Zhang">Jingke Zhang</name><name sortKey="Zheng, Xiaoke" sort="Zheng, Xiaoke" uniqKey="Zheng X" first="Xiaoke" last="Zheng">Xiaoke Zheng</name></country><country name="Hong Kong"><noRegion><name sortKey="Chen, Yingjie" sort="Chen, Yingjie" uniqKey="Chen Y" first="Yingjie" last="Chen">Yingjie Chen</name></noRegion><name sortKey="Yu, Zhiling" sort="Yu, Zhiling" uniqKey="Yu Z" first="Zhiling" last="Yu">Zhiling Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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